Post-transcriptional regulation of antiviral gene expression by N6-methyladenosine
نویسندگان
چکیده
منابع مشابه
Post-Transcriptional Regulation of Papillomavirus Gene Expression
Papillomavirus genomes are transcribed as one large complex transcription unit with multiple promoters, two poly(A) sites (early and late), and considerable alternative splicing. As a result, there are multiple opportunities for post-transcriptional regulation of papillomavirus gene expression. Although this area has not been as extensively studied as transcriptional regulation, there are a few...
متن کاملN6-methyladenosine-dependent regulation of messenger RNA stability
N-methyladenosine (mA) is themost prevalent internal (non-cap) modificationpresent in themessengerRNAofall higher eukaryotes. Although essential to cell viability and development, the exact role ofmAmodification remains tobedetermined.The recent discovery of twomAdemethylases inmammalian cells highlighted the importance of mA in basic biological functions and disease. Here we show that mA is se...
متن کاملDownregulation of N6-methyladenosine binding YTHDF2 protein mediated by miR-493-3p suppresses prostate cancer by elevating N6-methyladenosine levels
Recent evidence suggests that m6A modifications regulate the progressions of several types of tumors. YTHDF2, an m6A reader, has been implicated in the regulation of hepatocellular carcinoma (HCC). miR-493-3p has been defined as tumor suppressor that inhibits the progressions of several types of cancers. However, the functions and mechanisms of YTHDF2 and the indirect m6A regulated role of miR-...
متن کاملPost-transcriptional regulation of pro-inflammatory gene expression
The cytokine tumour necrosis factor (TNF)alpha is a vital mediator of the innate immune response, and a pleiotropic regulator of cellular function. Its involvement in rheumatoid arthritis is illustrated by the clinical benefits of TNF alpha blockade. Post-transcriptional regulation (the control of mRNA stability and translation) appears to play a critical role in the regulation of TNF alpha exp...
متن کاملTranscription and post-transcriptional regulation of avian HSP70 gene expression.
Transient incubation of chicken lymphoblastoid (MSB) cells at elevated temperatures induces the synthesis of three heat shock proteins of 89,000 Da (HSP89), 70,000 Da (HSP70), and 23,000 Da (HSP23). We have examined the effects of heat shock on the transcription and post-transcriptional regulation of the chicken HSP70 and beta-actin genes. The rate of HSP70 transcription is rapidly induced by h...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Reports
سال: 2021
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2021.108798